Corrigendum: Intestinal microbiota as a tetrahydrobiopterin exogenous source in hph-1 mice
نویسندگان
چکیده
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
منابع مشابه
Intestinal microbiota as a tetrahydrobiopterin exogenous source in hph-1 mice
Tetrahydrobiopterin (BH4) is a cofactor of a number of regulatory enzymes. Although there are no known BH4 exogenous sources, the tissue content of this biopterin increases with age in GTP cyclohydrolase 1-deficient hyperphenylalaninemia-1 (hph-1) mice. Since certain bacteria are known to generate BH4, we hypothesize that generation of this biopterin by the intestinal microbiota contributes to ...
متن کاملRole of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: treatment with folic acid.
It has been shown that endothelial NO synthase (eNOS) uncoupling occurs in hypertension and atherosclerosis. However, its causal role in vascular pathogenesis has not been characterized previously. Here, we challenged eNOS preuncoupled hyperphenylalaninemia (hph)-1 mice (deficient in eNOS cofactor tetrahydrobiopterin biosynthetic enzyme GTPCHI) with angiotensin II (Ang II; 0.7 mg/kg per day, 14...
متن کاملReactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin-deficient mice.
(6R)-5,6,7,8-Tetrahydro-biopterin (H(4)B) is essential for the catalytic activity of all NO synthases. The hyperphenylalaninemic mouse mutant (hph-1) displays 90% deficiency of the GTP cyclohydrolase I, the rate-limiting enzyme in H(4)B synthesis. A relative shortage of H(4)B may shift the balance between endothelial NO synthase (eNOS)-catalyzed generation of NO and reactive oxygen species. The...
متن کاملTetrahydrobiopterin deficiency exaggerates intimal hyperplasia after vascular injury.
Decreased levels of tetrahydrobiopterin (BH4), an absolute cofactor for nitric oxide synthase (NOS), lead to uncoupling of NOS into a superoxide v. nitric oxide producing enzyme, and it is this uncoupling that links it to the development of vascular disease. However, the effects of in vivo deficiency of BH4 on neointimal formation after vascular injury have not been previously investigated. Hph...
متن کاملDevelopment of Methodology and Data Acquisition
Infantile hypertrophic pyloric stenosis (IHPS): A study of its pathophysiology utilizing the newborn 1 hph-1 mouse model of the disease 2 3 Running Title: Rho-kinase and infantile pyloric stenosis 27 28 29 30 31 Abstract 33 Infantile hypertrophic pyloric stenosis (IHPS) is a common disease of unknown etiology. The 34 tetrahydrobiopterin (BH4)-deficient hph-1 newborn mouse has a similar phenotyp...
متن کامل